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ACEL, Inc. is CRO of Cell-based Assays.

TEL. 042-770-9482

〒252-0131 神奈川県相模原市緑区西橋本 5-4-21
さがみはら産業創造センター SIC-1 1201号室(受付)、1210号室

CRO
List of Cell-based Assays
Cell Based Assay

List of Cell-based Assays

Cosmetology field(cell-based assays)
  • Melanin production suppression test
       (suppression of melanin synthesis for whitening)
  • Fibroblast function promotion test
      (collagen promotion, hyaluronic acid production, etc.)
  • Epidermal cell test: ultraviolet (UV) protection of skin
      (protects skin from stress, such as UV rays)
  • Skin moisturizing/barrier function gene expression analysis
       (moisturizing using epidermal cells and promoting barrier function)
  • Dry stress protection test for skin and cornea
      (protection of dry skin and improvement of dry eye)
  • An activation test of dermal papilla cells
      (the functional substance that promotes hair formation)
  • An activation test of various cells: a cell proliferation promotion/suppression test
       (cosmetology, wound healing, suppression of cancer cells, etc.)
  • Cell migration test
       (wound healing, etc.)
  • Atopic dermatitis improvement test
       (search for substances that improve atopy, etc.)
Cosmetology field (biochemical test)
  • Collagenase activity inhibition test
       (control of collagen degradation))
  • Tyrosinase activity inhibition test
       (inhibition of melanin synthesis for whitening)
Health field (immune system)
  • Immune function regulation test
       (cytokine gene expression in macrophages)
  • Histamine release suppression test
       (excessive allergic reaction suppression by histamine)
  • Cytokine production measurement test
       (measurement of cytokines released from various cells)
  • Multiplex measurement
       (simultaneous measurement of multiple biomolecules, including cytokines)
  • Immune (blood) function improvement test
       (ability to promote differentiation into each blood cell)
  • Enteritis suppression test
       (effect of suppressing intestinal inflammation)
  • Pulmonary function improvement test
       (effect of suppressing intestinal inflammation)
Health field(anti-obesity system)
  • Fat differentiation suppression test
       (search for functional substances expected to have a diet effect)
  • Lipolysis promotion test
       (search for functional substances expected to have a diet effect)
  • Fat function improvement test
       (search for functional substances expected to have a diet effect)
  • Cell mitochondrial activation test
      (search for functional substances that promote fat burning, etc.)
  • Sugar uptake test of various cells
       (search for substances with anti-diabetes and diet effects)
Health field(blood system)
  • Blood vessel function improvement test
      (vasodilatory action, antithrombotic action, etc.)
  • Angiogenesis test
       (search for wound healing agents and cancer suppressants)
  • Antiarteriosclerosis test
      (search for drugs that suppress the occurrence and progression of arteriosclerosis)
Health field (bone/cartilage system)
  • Bone metabolism test using osteoblasts and osteoclasts
       (supporting bone health))
  • Chondrocyte function improvement test
       (treatment and prevention of joint diseases, etc.)
Health field (liver system)
  • Liver function improvement test
       (correlation between drug and CYP as well as drug efficacy)
Health field (nervous system)
  • Nerve cell function promotion test
       (improvement effect on neurological diseases)
  • NGF (Nerve growth factor) production promotion test
       (nerve cell differentiation and regeneration, neurodegenerative diseases)
Health field(muscular system)
  • Muscle building test using myoblasts
      (increasing and maintaining muscle mass)
  • Energy production promotion test using myotube cells
      (energy production promotion effect of muscle mass)
Health field(others)
  • Nicotinamide adenine dinucleotide phosphate oxidase activity measurement
       (control of active oxygen production)
  • Apoptosis induction test
       (induction of cell death by apoptosis, etc.)
  • Cancer cell infiltration inhibition test
       (cancer cell expansion, metastasis suppression, etc.)
  • Autophagy promotion test
       (cell autophagy activation, etc.)
  • Energy metabolism test
       (test using a flux analyzer)
Induced pluripotent stem (iPS) cells
  • Tests using
       iPS cells (examination of iPS cell culture conditions and differentiation induction conditions, etc.)
Animal experiment (alternative field)
  • Melanin production suppression test (three-dimensional cultured skin model)
       (whitening agent, raw material for whitening cosmetics)
Molecular biology field
  • Gene expression analysis
       (Ribonucleic acid [RNA] is extracted from cells and subjected to real-time polymerase chain reaction)
  • Comprehensive gene expression analysis (Deoxyribonucleic acid [DNA] microarray)
       (measurement of each RNA amount in cells)
  • Gene knockdown test using small interfering RNA (siRNA)
      (inhibition of gene expression in cells)
  • Cell-forced gene expression test
       (overexpression)
  • Western blotting
       (protein expression analysis using simple western blotting)
Base material evaluation
  • Base material evaluation test
       (evaluation of affinity between base material and cells, etc.)
Imaging
Plate reader
  • Measurement of fluorescence, emission, and absorption using a plate reader
       (quantification of each substance using a plate reader, etc.)
Flow cytometry
Tissue dispersion/crushing
  • Tissue/crushing test
      (tissue dispersion/crushing using gentleMACS, etc.))

* The above test is an example.

* We will establish custom-made tests and experimental methods that meet the needs of our customers.
Please feel free to contact us.

バナースペース

ACEL, Inc.

SIC-2 2611 ,5-4-30
Nishihashimoto, Midori-ku,
Sagamihara, Kanagawa, 252-0131 Japan

TEL:+81-42-770-9482
FAX:+81-42-770-9483